What’s the Difference Between Sodium Hyaluronate and Hyaluronic Acid? Intravesical treatment for interstitial cystitis the solution coats the lining of the bladder to significantly reduce pain and improve quality of life.Joint injections to treat osteoarthritis, which occurs due to diminishing levels of hyaluronic acid this serves to lubricate and cushion joints, and reduce pain.Eye drops to treat dry eye these drops act as a lubricant to moisten and soothe the eye.In addition to skin care products, sodium hyaluronate also plays a role in treating several medical conditions, and is a primary ingredient in: Different formulas are available for both the face and body. Sodium hyaluronate can be found in a range of skin care products including serums, creams, gels, lotions and face washes. Sodium hyaluronate is a key ingredient in multiple skin care products as it offers superior hydration by drawing in moisture to deeply hydrate and plump skin, and support collagen. It is used in various forms for medicinal purposes as well as cosmetic skin care products. This smaller molecule weight enables greater penetration and hydration at deeper levels. Sodium hyaluronate is a sodium salt that’s been synthesized to form smaller molecules for stability and oxidation resistance. Sodium Hyaluronate Safety and Side Effects.What’s the Difference Between Sodium Hyaluronate and Hyaluronic Acid?.Allergic reaction to hyaluronidase use after hyaluronic acid filler injection. Hyaluronidase: An overview of its properties, applications, and side effects. Use of hyaluronidase in patients with bee allergy. Reassessing the role of hyaluronidase in yellow jacket venom allergy. Jin C, Focke M, Léonard R, Jarisch R, Altmann F, Hemmer W. Allergic reaction to hyaluronidase after retrobulbar anaesthesia: a case series and review. Ledford for his insight and hope you find this dialog helpful in the management of your patient.ĭelaere L, Zeyen T, Foets B, Van Calster J, Stalmans I. Shared decision making with the patient is essential. Hopefully, neither are reactive and this information may be reassuring to the patient about the products in question. Ledford suggests a reasonable approach is to perform a SPT with the products your patient is expected to be given. Kim and others discuss their skin testing protocol using controls, prick and ID methods, and a similar product. Skin testing using 3 IU of hyaluronidase is referenced in the overview by Jung. The potential for an allergic reaction is these patients is not addressed in the package insert as such. There is no clear-cut answer to the use of hyaluronidase in patients allergic to the Aspids or Vespidae Hymenoptera. Have you definitively established insect sting allergy? You indicated that 'venom skin testing is pending'. However, these patients are frequently immunosuppressed and may be less likely to show reactivity. Dennis Ledford reminded me that purified hyaluronidase is used in SQ gamma globulin and he is not aware of any reactions related to this ingredient. My colleague and ATE steering panel advisor, Dr. Adverse reactions include allergic reactions in less than 0.1% of patients receiving hyaluronidase. It does not specify contraindications related to insect sting allergy. The package insert states its use is contraindicated in patients with known hypersensitivity to hyaluronidase or any of the excipients in Hylenex recombinant. It is used for other on-label and off-label indications to include dissolving hyaluronic acid fillers (off-label). Hyaluronidase human injection is also used in retrobulbar anesthesia during ophthalmic surgery to improve the efficacy and speed of nerve blocks. One of the most widely used forms of therapeutic hyaluronidase in dermatology, Hylenex recombinant (hyaluronidase human injection) is an endoglycosidase that breaks down hyaluronic acid, a key component in connective tissue and is indicated as an adjuvant to increase the dispersion and absorption of other injected drugs. The presence of cross-reactive carbohydrate determinants is thought to explain IgE binding and cross reactivity with another. Yellow jacket hyaluronidase shows 50% homology with the hyaluronidase from honeybee venom. The venoms of both the Aspids and Vespidae Hymenoptera contain hyaluronidase amongst an array of other allergenic components. I have attached several references in the preparation of this response.The incidence of pure hyaluronidase allergy is reported as rare, 1/2000. After searching the literature I was unable to find an abundance of literature on this topic to include case reports or even retrospective reviews.
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